Ashley Cole is back in the starting line-up so makes his 300th Chelsea appearance.
Demba Ba returns to lead the attack and Thursday’s last-gasp goalscorer Eden Hazard also starts.
Gary Cahill and David Luiz are the centre-back partnership so Frank Lampard will captain the side.
Man City’s attack will be led by Sergio Aguero with Edin Dzeko and Carlos Tevez on the bench. Vincent Kompany has failed in his race to be fit so Matija Nastastic continues in central defence.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech
2 Branislav Ivanovic
24 Gary Cahill
4 David Luiz
3 Ashley Cole
12 John Mikel Obi
8 Frank Lampard (c)
7 Ramires
10 Juan Mata
17 Eden Hazard
29 Demba Ba
Substitutes: 22 Ross Turnbull, 28 Cesar Azpilicueta, 26 John Terry, 34 Ryan Bertrand, 11 Oscar, 13 Victor Moses, 9 Fernando Torres.
Man City are expected to line up in the following 4-2-3-1 formation:
Hart; Zabaleta (c), K Toure, Nastasic, Clichy; Rodwell, Javi Garcia; Milner, Y Touré, Silva; Agüero.
Substitutues: Pantilimon, Kolarov, Lescott, Nasri, Sinclair, Tevez, Džeko.
The referee is Andre Marriner.
Follow the game via our Live Matches from 12.30am (UK time).