Demba Ba returns to lead the attack and Juan Mata is also back in the starting line-up.
In defence, Cesar Azpilicueta and Gary Cahill replace Branislav Ivanovic and John Terry.
Ramires and Victor Moses, who didn’t make the trip to Romania, also start.
For Man United, Wayne Rooney will partner Javier Hernandez up front with Robin van Persie on the bench.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech
28 Cesar Azpilicueta
4 David Luiz
24 Gary Cahill
3 Ashley Cole
8 Frank Lampard (c)
13 Victor Moses
10 Juan Mata
29 Demba Ba
Substitutes: 22 Ross Turnbull, 2 Branislav Ivanovic, 26 John Terry, 34 Ryan Bertrand, 12 John Mikel Obi, 17 Eden Hazard, 9 Fernando Torres.
Man United are expected to line up in the following 4-4-2 formation:
De Gea; Rafael, Evans, Ferdinand, Evra; Nani, Carrick, Cleverley, Young; Rooney, Hernandez.
Subs: Amos, Valencia, Anderson, Vidic, Young, Welbeck, van Persie.
The referee is Howard Webb.
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