Unsurprisingly, with such a congested fixture list Rafael Benitez once again makes a number of changes to the side from the previous game.
With both Ashley Cole and Ryan Bertrand unavailable, there is a rare start for Paulo Ferreira at left-back, while captain John Terry also returns to the side.
In midfield, 18-year-old Nathan Ake makes only his second start alongside Frank Lampard, with Ramires playing in a more advanced role wide on the right.
With Juan Mata and Eden Hazard both starting on the bench, there are opportunities for Yossi Benayoun and Victor Moses, while Fernando Torres starts up front.
Chelsea are expected to line up in the following 4-2-3-1 formation:
Substitutes: 22.Turnbull (GK), 2.Ivanovic, 12.Mikel, 11.Oscar, 17.Hazard, 21.Marin, 10.Mata.
Rubin Kazan are expected to line up in the following 4-4-1-1 formation:
1.Rhyzhikov; 2. Kuzmin, 4.Cesar Navas, 25.Marcano, 3.Ansaldi; 6.Orbaiz, 10.Kasaev, 61.Karadeniz (c), 66.Natcho; 23.Eremenko; 99.Rondon.
Substitutes: 24.Arlauskis (GK), 19.Kaleshin, 76.Sharonov, 8.Ryazantzev, 15.Kislyak, 55.Tore, 22.Dyadyun.