Jose Mourinho makes three changes to the side which beat Everton 1-0 on Saturday.
The back four remains unchanged but in midfield, with Nemanja Matic ineligible, Ramires partners Frank Lampard.
Andre Schurrle makes his first start since our FA Cup fourth round win over Stoke City, while there is also a return to the starting line-up for Fernando Torres.
For the home side, Didier Drogba leads the line as expected, while there are other familiar faces in the shape of Emmanuel Eboue and Wesley Sneijder.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1.Cech; 2.Ivanovic, 24.Cahill, 26.Terry (c), 28.Azpilicueta; 7.Ramires, 8.Lampard; 22.Willian, 17.Hazard, 14.Schurrle; 9.Torres
Substitutes: 23.Schwarzer, 3.Cole, 33.Kalas, 12.Mikel, 11.Oscar, 19.Ba, 29.Eto’o
Galatasaray, meanwhile, are expected to line up in the following 4-2-3-1 formation:
25.Muslera; 27.Eboue, 21.Chedjou, 22.Balta, 15.Telles; 3.Melo, 8.Inan; 14.Hajrovic, 17.Yilmaz, 10.Sneijder; 11.Drogba
Substitutes: 86.Ceylan, 6.Gulselam, 19.Bulut, 26.Kaya, 35.Kertulus, 52.Colak, 55.Sarioglu
Tonight’s referee is Carlos Carballo from Spain.
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