Roberto Di Matteo makes two changes from the Tottenham starting line-up.
John Terry returns in place of Gary Cahill and in midfield, Frank Lampard, who is playing his 100th European game for Chelsea, is reintroduced with Ramires moving into a more forward position on the right, Eden Hazard making way. The Belgian is on the bench.
Shakhtar name the same team that earned a draw away to Juventus in their last Champions League match.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech
2 Branislav Ivanovic
4 David Luiz
26 John Terry (c)
3 Ashley Cole
12 John Mikel Obi
8 Frank Lampard
10 Juan Mata
9 Fernando Torres
Substitutes: 22 Ross Turnbull, 28 Cesar Azpilicueta, 34 Ryan Bertrand, 24 Gary Cahill, 6 Oriol Romeu, 17 Eden Hazard, 23 Daniel Sturridge.
Shakhtar are expected to line up in the following 4-2-3-1 formation:
Pyatov; Srna (c), Kucher, Rakitskiy, Rat; Fernandinho, Hübschman; Texeira, Mkhitaryan, Willian; Luiz Adriano.
Subs: Kanibolotskiy, Kryvstov, Douglas Costa, Ilsinho, Stepanenko, Gai, Eduardo.
The referee is Damir Skomina from Slovenia.
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