David Luiz, fit again after an ankle injury, returns to the side but John Terry starts on the bench. Branislav Ivanovic reverts to right-back.
Juan Mata is also back from injury so the familiar trio with Oscar and Eden Hazard is restored behind striker Fernando Torres.
Ryan Bertrand replaces hamstrung Ashley Cole at left-back.
Shakhtar Donetsk are unchanged from the game in Ukraine a fortnight ago.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech
2 Branislav Ivanovic
24 Gary Cahill
4 David Luiz
34 Ryan Bertrand
12 John Mikel Obi
17 Eden Hazard
10 Juan Mata
9 Fernando Torres
Substitutes: 22 Ross Turnbull, 28 Cesar Azpilicueta, 26 John Terry, 6 Oriol Romeu, 21 Marko Marin, 13 Victor Moses, 23 Daniel Sturridge.
Shakhtar are expected to line up in the following 4-2-3-1 formation:
Pyatov; Srna (c), Kucher, Rakitskiy, Rat; Fernandinho, Hübschman; Texeira, Mkhitaryan, Willian; Luiz Adriano
Subs: Kanibolotskiy, Shevchuk, Chygrynkiy, Ilsinho, Stepanenko, Douglas Costa, Eduardo.
The referee is Carlos Velasco Carballo from Spain.
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