Fernando Torres will lead the attack with Oscar, Kevin De Bruyne and Eden Hazard the three players behind.
John Terry is partnered by Gary Cahill in central defence with David Luiz out injured and with Cesar Azpilicueta having travelled to South America for an international midweek, Branislav Ivanovic is at right-back.
Juan Mata has recovered sufficiently from injury to be on the bench.
Hull include five new signings in their starting 11 but former Tottenham pair Tom Huddlestone and Jake Livermore are among the subs.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech; 2 Branislav Ivanovic, 24 Gary Cahill, 26 John Terry (c), 3 Ashley Cole; 7 Ramires, 8 Frank Lampard; 15 Kevin De Bruyne, 11 Oscar, 17 Eden Hazard; 9 Fernando Torres.
Substitutes: 23 Mark Schwarzer, 5 Michael Essien, 16 Marco van Ginkel, 14 Andre Schurrle, 10 Juan Mata, 29 Demba Ba, 18 Romelu Lukaku.
Hull are expected to line up in the following 4-3-3 formation:
McGregor; Elmohamady, Chester, Davies, Figueroa, Koren, Meyler, Brady, Aluko, Graham, Sagbo.
Substitutues: Harper, Rosenior, McShane, Livermore, Huddlestone, Boyd, Bruce.
The referee is Jon Moss.
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