Fit again Fernando Torres leads the attack, with German international Andre Schurrle back in the side as he returns to his homeland.
Elsewhere, Jose Mourinho will pick either Branislav Ivanovic or Cesar Azpilicueta out of position at left-back, with Ryan Bertrand on the bench and Ashley Cole unavailable.
The manager also recalls Gary Cahill alongside captain John Terry, with Schurrle joined by weekend goalscorer Eden Hazard and Oscar behind Torres.
Schalke field former Spurs and Portsmouth man Kevin-Prince Boateng, while Jermaine Jones is also fit to start.
Chelsea are expected to line up in the following 4-2-3-1 formation:
1 Petr Cech; 2 Branislav Ivanovic, 24 Gary Cahill, 26 John Terry ©, 28 Cesar Azpilicueta; 7 Ramires, 8 Frank Lampard; 17 Eden Hazard, 11 Oscar, 14 Andre Schurrle.
Substitutes: 23 Mark Schwarzer, 4 David Luiz, 34 Ryan Bertrand. 12 John Mikel Obi, 22 Willian, 10 Juan Mata, 29 Samuel Eto’o.
The Schalke line up is:
Hildebrand; Uchida, Howedes ©, Matip, Aogo; Jones, Neustatder; Clemens, Meyer, Draxler; Boateng.
Substitutes: Fahrmann, Hoogland, Felipe Santana, Kolasinac, Fuchs, Goretzka, Szalai.
The referee is Viktor Kassai from Hungary.
You can follow the game live here on the Chelsea website from 7.30pm (UK time).