Mark Schwarzer starts in goal and David Luiz returns from suspension so John Terry is able to take a rest.
John Mikel Obi makes his 300th appearance for Chelsea with Michael Essien partnering him in central midfield, the Ghanaian also wearing the captain’s armband.
Oscar and Willian are retained following their impact as subs against Southampton and Samuel Eto’o leads the attack.
Lewis Baker, an 18-year-old midfielder yet to make his debut, is on the bench, as is young centre-back Tomas Kalas.
Derby make two changes to from their defeat by Wigan, Jeff Hendrick comes into midfield and Simon Dawkins, freshly signed from Spurs following a loan comes in wide on the left of the attack.
Chelsea are expected to line up in the following 4-2-3-1 formation:
23 Mark Schwarzer; 28 Cesar Azpilicueta, 24 Gary Cahill, 4 David Luiz, 3 Ashley Cole; 5 Michael Essien (c), 12 John Mikel Obi; 7 Ramires, 11 Oscar, 22 Willian; 29 Samuel Eto’o.
Substitutes: 1 Petr Cech, 33 Tomas Kalas, 26 John Terry, 47 Lewis Baker, 17 Eden Hazard, 10 Juan Mata, 9 Fernando Torres.
Derby are expected to line up in the following 4-3-3 formation:
Grant; Wisdom, Keane, Buxton (c), Forsyth; Hughes, Eustace, Hendrick; Ward, Martin, Dawkins.
Substitutues: Legzdins, Whitbread, Bailey, Cisse, Sammon, Bennett, Freeman.
The referee is Andre Marriner.
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