Mauricio Pochettino team play host to rivals Chelsea at Wembley on Sunday afternoon, as Spurs play their first ever Premier League home game at the national stadium.
Coming into the game on the back of a clinical display against a depleted Newcastle team, the North Londoners meet the Blues, who are potentially on the brink of a mini crisis.
The Blues head into this game following a shock opening day defeat to Burnley, in which both Gary Cahill and Cesc Fabregas received red cards. Chelsea are already without attacking star Eden Hazard, while Diego Costa remains in exile.
Here are the key battles which could decide this early season blockbuster.
1. Harry Kane vs Andreas Christensen
The talismanic Harry Kane will hope to bring an end to his August hoodoo, having somehow failed to score in the the first month of the season in his teams last eleven games.
Fantasy football managers everywhere will be hoping that he can break this duck against what could be a less cohesive Chelsea back line, with Andreas Christensen and Antonio Rudiger being brought into the side.
It is the former who will be primarily tasked with keeping the Englishman quiet. Following a successful two year spell in Germany with Borussia Moenchangladbach, the Dane will see this as the perfect opportunity to lay claim to a more permanent starting berth.
2. Mousa Dembele vs Ngolo Kante
It is in midfield where the most interesting battle of the day will take place, with the mercurial Dembele coming up against much admired workhorse Ngolo Kante in the middle of the park.
If the Belgian, alongside physical enforcer Victor Wanyama, can gain the upper hand, there is little doubting Spurs’ ability to take the game away from their rivals.
However, the loss of Cesc Fabregas could prove to be a blessing in disguise, with centre back David Luiz easing the physical strain that Kante would otherwise have found himself under, allowing the Frenchman to operate more freely in his role.
3. Willian vs Ben Davies
Davies has been simply superb in 2017, seamlessly replacing the injured Danny Rose at the end of last season and the start of this. Having opened his scoring account with a goal against Newcastle, he will look to continue his form here.
Willian, meanwhile, will be heavily relied upon by his team as a creative outlet, with Cesc Fabregas, Eden Hazard and Pedro all missing for this game. He can expect to see plenty of the ball on the right hand side, and his excellent set pieces could prove vital down the stretch.