The Blues have not played the Pilgrims since 1989 and the current Plymouth side ply their trade in League One, where they occupy the final play-off place.
Chelsea are looking to win our first FA Cup trophy since the 2017/18 campaign, where an Eden Hazard penalty ensured we beat Manchester United 1-0 at Wembley.
At this stage last season, the Blues were paired with Luton Town at Stamford Bridge, with a hat-trick from Tammy Abraham ensuring a 3-1 win and our passage into the fifth round.
The ties are set to take place across the weekend of February 4 and February 7. Due to our involvement in the Club World Cup, a date for our fixture will be confirmed in due course.